Transmembrane Mucins: Signaling Receptors at the Intersection of Inflammation and Cancer.van Putten JP, Strijbis K.J Innate Immun. 2017 Jan 5. Mucosal surfaces line our body cavities and provide the interaction surface between commensal and pathogenic microbiota and the host. The barrier function of the mucosal layer is largely maintained by gel-forming mucin proteins that are secreted

Host cell binding of the flagellar tip protein of Campylobacter jejuni. Freitag CM, Strijbis K, van Putten JP.Cell Microbiol. 2016 Dec 22. Flagella are nanofibers that drive bacterial movement. The filaments are generally composed of thousands of tightly packed flagellin subunits with a terminal cap protein, named FliD. Here we report that the FliD protein of the bacterial pathogen

Feedback control of Campylobacter jejuni flagellin levels through reciprocal binding of FliW to flagellin and the global regulator CsrA. Radomska KA, Ordoñez SR, Wösten MM, Wagenaar JA, van Putten JP.Mol Microbiol. 2016 Jun 29. Bacterial flagella assembly is tightly regulated to ensure a timely and sequential production of the various flagellum constituents. In the pathogen Campylobacter jejuni the hierarchy

Meet up for the latest developments in ‘Innate host defence and infections’ Scientists from academia and industry are invited to attend the second ALTANT Conference to discuss recent scientific advances in the exploitation of innate host defence mechanisms to combat infections.The conference will be held from 18-20 May 2016 in Utrecht, the Netherlands. The purpose of

Reptile Toll-like receptor 5 unveils adaptive evolution of bacterial flagellin recognition. Voogdt CG, Bouwman LI, Kik MJ, Wagenaar JA, van Putten JP.Sci Rep. 2016 Jan 7;6:19046. Toll-like receptors (TLR) are ancient innate immune receptors crucial for immune homeostasis and protection against infection. TLRs are present in mammals, birds, amphibians and fish but have not been functionally characterized in reptiles despite

Redirection of Epithelial Immune Responses by Short-Chain Fatty Acids through Inhibition of Histone Deacetylases. Lin MY, de Zoete MR, van Putten JP, Strijbis K.Front Immunol. 2015 Nov 3;6:554.  Short-chain fatty acids (SCFAs) are products of microbial fermentation that are important for intestinal epithelial health. Here, we describe that SCFAs have rapid and reversible effects on toll-like receptor (TLR) responses

Dr. Marcel de Zoete (Infectieziekten en Immunologie) heeft van NWO een Vidi-financiering gekregen van maximaal 800.000 euro. Hiermee kan hij gedurende vijf jaar een eigen onderzoekslijn ontwikkelen en een onderzoeksgroep opbouwen. ONDERZOEK NAAR MICROBIOTA.Het onderzoek van Marcel de Zoete richt zich op de microbiota. De menselijke darm wordt bewoond door miljarden bacteriën: de microbiota. Hoewel het grootste

The Campylobacter jejuni RacRS two-component system activates the glutamate synthesis by directly upregulating γ-glutamyltranspeptidase (GGT). van der Stel AX, van Mourik A, Łaniewski P, van Putten JP, Jagusztyn-Krynicka EK, Wösten MM Front Microbiol. 2015 Jun 5;6:567. The highly conserved enzyme γ-glutamyltranspeptidase (GGT) plays an important role in metabolism of glutathione and glutamine. Yet, the regulation of ggt transcription in prokaryotes is poorly understood. In